Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy

Table 1.

Inputs for the different methods evaluated

Method BOLT/GCTA-GREML, RHE SUM-RHE LDSC SumHer
Inputs Individual genotype Ref. trace Ref. LD scores Ref. SNP tag
Individual phenotype GWAS summary GWAS summary GWAS summary

  • LDSC and SUM-RHE rely only on the summary statistics, whereas GCTA-GREML, BOLT-REML, and RHE require individual data for target genotypes and phenotypes.

This Article

  1. Published in Advance July 22, 2024, doi: 10.1101/gr.279207.124 Genome Res. 34: 1286-1293

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