ASB analysis assists with fine-mapping eQTLs. (A) Genomic tracks for the 100 kb region surrounding rs10132528. (First) Maximum −log10(P-value) of all TFs for heterozygous variants in Donor1. (Second) GTEx eQTLs for BEGAIN colored by overlap with heterozygous variants in Donor1. (Third) ENCODE cCREs. (Fourth) Gene annotations from Ensembl v86. (B) Stacked bar plots showing the number of RNA reads supporting haplotype1 or haplotype2 for BEGAIN (top) and WDR25 (bottom). (C) The proportion of ChIP-seq reads for CTCF (left), RAD21 (middle), and SMC3 (right) supporting the reference and alternate allele for each brain region where the TF was profiled. (D) Position of the JASPAR CTCF motif on Chr 14 with the position of ASB variant indicated in red. (E) MotifbreakR score for the reference and alternate allele for rs10132528.
