Yanina Timasheva; Kaido Lepik; Orsolya Liska; Balázs Papp; Zoltán Kutalik

Widespread natural selection on metabolite levels in humans

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Figure 1.

Metabolites with selection estimates showing stabilizing selection ( $\text{[math]}$ < 0) and disruptive selection ( $\text{[math]}$ > 0). Circle symbols represent nonsignificant selection estimates; triangles refer to metabolites with a selection strength P-value surviving multiple testing correction (P < 0.05/97). Error bars represent SEs. Metabolites showing exceptionally large SEs are indicated by an asterisk, such as PC ae C32:1 (SE = 98.5) and PC ae C44:5 (SE = 86.1).