Accurate estimation of pathway activity in single cells for clustering and differential analysis

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 3.
Figure 3.

SiPSiC shows improved accuracy compared with AUCell, ssGSEA, and VAM. Violin plots showing normalized pathway score distributions as calculated by the four different methods. Significant results (FDR < 0.01) are colored red. (Top) Apoptosis, monkey alveolar cells. (Middle) TGF beta signaling, human B cells. (Bottom) G2/M checkpoint, human CD8+ T cells.

This Article

  1. Published in Advance July 9, 2024, doi: 10.1101/gr.278431.123 Genome Res. 34: 925-936

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research