Figure 1.
SiPSiC detects differential activity of hallmark pathways in SARS-CoV-2-infected alveolar cells. (A,B) Heatmaps depicting Z-scores of SiPSiC scores of alveolar cells for all differential hallmark pathways (FDR < 0.01) for COVID-19 patients and the control group (A) or SARS-CoV-2-infected monkeys and controls (B). Each row represents one hallmark pathway, and the pathway name is listed on the right. Pathways are sorted by significance of differential scores; cells in each cell group are sorted by their average Z-score across all pathways upregulated in that group. Pathway names mentioned in the text are colored red.
