Simultaneous assessment of human genome and methylome data in a single experiment using limited deamination of methylated cytosine

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Performance of RIMS-seq2 (DNA sequencing). (A) Germline transitions/transversion profiles for JIMB and RIMS-seq2 WGS for homozygous (top) and heterozygous (bottom) SNPs. In all cases, transitions represent the majority of the SNPs identified. (B) Precision of variant calling for standard DNA-seq and RIMS-seq2 targeted-exome sequencing. (C) Precision, sensitivity, and F-score for WGS RIMS-seq2 (full data set and downsampled to 30-fold coverage). (D) The effect of the DP filter on precision.

This Article

  1. Published in Advance June 10, 2024, doi: 10.1101/gr.278294.123 Genome Res. 34: 904-913

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research