Genome-wide relaxation of selection and the evolution of the island syndrome in Orkney voles

Table 1.

The 10 most significantly enriched GO biological process terms of genes that experienced hard sweeps in continental voles with the lowest Padj (P-value of enrichment adjusted with g:SCS method for multiple testing correction)

Term ID Term name Padj Term size Intersection size Relate to
GO:0036353 Histone H2A-K119 monoubiquitination 4.94 × 10−8 9 5 Histone
GO:0019373 Epoxygenase P450 pathway 1.43 × 10−6 34 6 Lipid
GO:0035518 Histone H2A monoubiquitination 3.28 × 10−6 18 5 Histone
GO:0006805 Xenobiotic metabolic process 6.64 × 10−6 122 8 Lipid
GO:0071466 Cellular response to xenobiotic stimulus 7.13 × 10−6 179 9 Lipid
GO:0006629 Lipid metabolic process 9.96 × 10−6 1371 20 Lipid
GO:0033522 Histone H2A ubiquitination 3.68 × 10−5 28 5 Histone
GO:0010390 Histone monoubiquitination 5.31 × 10−5 30 5 Histone
GO:0009410 Response to xenobiotic stimulus 7.89 × 10−5 316 10 Lipid
GO:0051276 Chromosome organization 8.2 × 10−5 981 16 Histone
  • Term size refers to the number of genes in the GO term. Intersection size refers to the number of genes under hard sweep. The GO terms listed are related to either histone monoubiquitination (histone) or lipid metabolism (lipid).

This Article

  1. Genome Res. 34: 851-862

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