Identification of cell types at the single-cell level in the hippocampus. (A) UMAP with five main cell type populations were annotated and color coded based on cell type identifications. (NEUR) Neuronal cell lineage, (OLG) oligodendrocyte cell lineage, (IMC) immune cell lineage, (ASC) astrocyte cell lineage, (EC) endothelial cell lineage. (B) UMAP with expression levels of cell type–specific marker genes identifying all five major cell populations. Legend color represents RNA density. Circles were added to visualize grouped cell populations. OLGs have high expression of Sox10; NEURs have high expression of Snap25; ECs have high expression of Esam; IMCs have high expression of Lcp1; and ASCs have high expression of Gja1. (C) Violin plot showing the distribution of expression levels of well-known representative cell type–enriched marker genes across five cell types, 27,804 cells in total. (D) Percentage of each cell type. (E) Number of detected genes per cell type.
