(See following page for legend.) Genetic diversity of dog breeds represented within Dog10K. (A) Individual site frequency spectrum (ISFS) from the Dog10K data set (Meadows et al. 2023). Each curve represents the number of variants that each dog carries and the MAF of those variants across the Dog10K cohort. Individual dogs were grouped according to the skewness of their ISFS curve. Most of the genetic variation for dogs in ISFS group 1 is common across dog populations, whereas dogs in ISFS group 4 carry a high number of variants that are rare within Dog10K. (B) ISFS group proportions for each Dog10K sample category (wolf, village dogs, or breed dogs). Height of the horizontal bars is proportional to the number of Dog10K dogs belonging to each category. (C) Distribution of singleton variants per individual, plotted according to ISFS group. (D) Degree of inbreeding for each dog depicted as the fraction of the genome within runs of homozygosity, plotted according to ISFS group. (E) Global distribution of dog breeds. Colors represent global regions, and depth of shading represents the number of breeds originating in each country. (F) Sample collection within the Dog10K Project is representative of global breed diversity. The number of breeds collected was proportional to the number of breeds that originated in each country. The size of the data point indicates the median breed population size collected within Dog10K. Data points are colored according to the global region of breed origin. (G) Number of Dog10K breed dogs per country that belong to each ISFS group depicted in A. Depth of shading in G and H represents the numbers of dogs in each category according to the key shown in E. (H) Number of Dog10K village dogs per country that belong to each ISFS group depicted in A.
