Genomic analyses help resolve the genetics of shared human–canine traits. (A) Approximately 50% of variance in dog breed body size is explained by association at seven genetic markers. The figure shows several combinations of small and large body-size alleles contributing to the heights of different breeds. Raw data provided by Rimbault et al. (2013). (B) Recurrent mutations in FBXW7 are a feature of canine lymphoma and human cancer. The figure shows a single-amino-acid site, R470, which accounts for 41% of all FBXW7 somatic mutations in a cohort of whole-exome-sequenced lymphoma samples. Data obtained from UCSC, originally provided by Elvers et al. (2015).
