
With over 350 recognized breeds, the large-scale analysis of canine genomes is uncovering the genetic basis of trait variation with regard to morphology, behavior, and disease susceptibility. In this issue, a mini-review discusses the global genetic diversity of dog breeds and identifies Asia as a source of missing canine genetic variation. Recent innovations in comparative genomics are also revealing the functional role of noncoding variation and its impact on phenotypic diversity. The cover art features the faces of four dog breeds, the Great Dane, Golden Retriever, Boxer, and German Shepherd Dog, highlighting the genetic and phenotypic diversity between breeds. (Cover design by Renée Mackenzie, vector artwork created using Kittl and Canva. [For details, see Buckley and Ostrander, pp. 811–821.])