Figure 8.
Summary of TFs driving GC epigenomic heterogeneity and EMT. (A) Differentially active TFs in Mes-like and Epi-like GC cell lines. (B) DNA CN changes in Mes-like and Epi-like GC cell lines. (C) Mes-like GC has a high correlation of expression and distal enhancer activity with fibroblasts, whereas Epi-like GC is more similar to the stomach. (D) Mes-like GC TF response and chromatin profile are different from that of fibroblasts, despite the shared patterns of expression and chromatin accessibility.
