Figure 5.
Comparison of DegCre associations from single-nucleus multiomics to Signac. (A) UMAP representation of single-nucleus RNA-seq and ATAC-seq from neuronal precursor cell differentiation time course from Rogers et al. (B) PR curve using Gasperini et al. CRISPR data as the standard. (PPV) Positive predictive value (precision), (TPR) true-positive rate (recall). Dashed red line indicates “zero skill” performance. DegCre associations were calculated on pseudobulked RNA and ATAC data. Signac (Stuart et al.) was applied to single-nucleus data to generate linkage scores.
