Navigating the landscape of epitranscriptomics and host immunity

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Figure 1.
Figure 1.

RNA modifications and their corresponding writer/editing enzymes: (A) N6-methyladenosine (m6A) deposited by a methyltransferase complex that includes the METTL3–METTL14 heterodimer, (B) 5-methylcytosine (m5C) deposited by the DNA methyltransferase homolog DNMT2 and methyltransferases from the NSUN family, (C) deamination of adenosine to inosine by ADAR enzymes, (D) deamination of cytosine to uracil by APOBEC proteins, and (E) conversion of uridine to pseudouridine (Ψ) by pseudouridine synthase enzymes. When applicable, the generic writer/editing enzyme name is depicted alongside the list of specific protein names. Pseudouridine synthases are grouped by family. Created with BioRender (https://www.biorender.com).

This Article

  1. Published in Advance May 3, 2024, doi: 10.1101/gr.278412.123 Genome Res. 34: 515-529

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