Systematic mapping of TF-mediated cell fate changes by a pooled induction coupled with scRNA-seq and multi-omics approaches

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

iTF-seq enables search for TFs with cell fate conversion potential. (A–C) UMAP plots of cells expressing individual iTFs and control cells after 1, 3, and 5 d of induction. Some iTF-expressing cells and control cells are marked with colors. (D) Relative expression levels of ESC markers (Pou5f1, Sox2, Nanog, and Klf4) in control and Otx2-, Elf5-, and Id2-expressing cells after 1, 3, and 5 d of induction.

This Article

  1. Published in Advance April 5, 2024, doi: 10.1101/gr.277926.123 Genome Res. 34: 484-497

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research