TASC carry more potential for increased functional variation but purge highly deleterious mutations more efficiently than other chromosomes. (A) SNP-derived allele frequency (DAF) along TASC. Each dot corresponds to a SNP; the y-axis to its DAF and the x-axis to Leish Chr 31 positions. (B,C) Boxplot (B) and density plot (C) comparing DAF from TASC and other chromosomes. (D) Proportion of ancestral homozygous (ancestral), heterozygous (Het), or derived homozygous (derived) genotypes in the 113 L. donovani isolates. Distribution of derived allele read depth (DARD) in heterozygous positions on TASC and other chromosomes, separated by high and low impact (E) or by −3 to 3 impact (F).
