Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors

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Figure 3.
Figure 3.

Activities of CREs near genes enriched in rod or cone photoreceptors. (A) Distribution of activity classes in +/+ retina for 66 and 117 CREs within 100 kbp of cone- or rod-enriched genes, respectively, as defined by Ruzycki et al. (2015). (B) Fold change relative to +/+ of 66 CREs near cone-enriched genes. (C) Fold change relative to +/+ of 117 CREs near rod-enriched genes. In B and C, rows are sorted by fold change in −/−.

This Article

  1. Published in Advance February 14, 2024, doi: 10.1101/gr.278133.123 Genome Res. 34: 243-255

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