RNA Pol II–dependent transcription efficiency fine-tunes A-to-I editing levels

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Figure 6.
Figure 6.

Differences in pre-mRNA and mRNA editing levels are reverted under conditions in which transcription is blocked. (A–C) RNA was isolated from primary neuronal cultures established from wild-type mouse embryos at E12.5 that were treated with actinomycin D in order to stall transcription. Subsequently, pre-mRNA and mRNA editing levels were determined using amplicon-sequencing. The log2FC in editing levels for pre-mRNA (blue) or mRNA (yellow) relative to the control without treatment at 0 h is plotted for 6 h (upper panel) and 24 h (lower panel), respectively (n = 6).

This Article

  1. Published in Advance March 12, 2024, doi: 10.1101/gr.277686.123 Genome Res. 34: 231-242

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