Table 2.
Tissue expression and Gene Ontology (GO) pathway analysis of selected lncRNA genes containing pG4, piM, or pRL structures
| Gene symbol | Ensembl Gene ID | Predicted structure type(s) | Tissue(s) | Main pathway(s) identified |
|---|---|---|---|---|
| MIAT | ENSG00000225783 | G4, iM, RL | Brain, pituitary | Cell fate specification/commitment, differentiation |
| H19 | ENSG00000130600 | G4, iM, RL | Placenta | Metabolism of purines, oxidative stress, ATP metabolism, hepatocyte apoptosis |
| ELFN2 (lncRNA variant) | ENSG00000243902 | G4, iM, RL | Brain, testis | Regulation of protein dephosphorylation |
| HOTAIR | ENSG00000228630 | G4 | Testis, skin | Epigenetic silencing of gene expression |
| MYCNOS | ENSG00000233718 | G4, iM | Testis | Negative regulation of protein phosphorylation |
| LINC01783 | ENSG00000233421 | G4, RL | Testis | Molecular adaptor activity—targets miRNA to promote cancer-associated pathways |
| LINC03126 | ENSG00000228549 | G4, RL | Testis | Molecular adaptor activity |
| SNAP25-AS1 | ENSG00000227906 | iM | Brain, pituitary | SRP-dependent cotranslational protein targeting to membrane (endoplasmic reticulum), signal sequence recognition |
| CDKN2B-AS1 | ENSG00000240498 | iM | Colon, small intestine | Epigenetic silencing of gene expression |
| GJD2-DT | ENSG00000250007 | iM, RL | Brain, heart, pituitary | SRP-dependent cotranslational protein targeting to membrane (endoplasmic reticulum), signal sequence recognition |
| TAB2 (lncRNA variant) | ENSG00000228408 | RL | Brain | MYD88-dependent TLR signaling pathway, JNK cascade, response to IL1 regulation of I kappa B kinase/NF-kB signaling, MAPK signaling pathway |
