Tyrosine 1–phosphorylated RNA polymerase II transcribes PROMPTs to facilitate proximal promoter pausing and induce global transcriptional repression in response to DNA damage

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Figure 7.
Figure 7.

Model of Y1P RNAPII-dependent PROMPTs facilitating down-regulation of PCGs upon DNA damage. Upon DSB induction, elevated ATM-dependent ABL1 activity causes greater enrichment of Y1P RNA Pol II near the promoter of PCGs and concomitantly enhanced expression of PROMPTs near PCGs. PROMPTs recruit PRC2, which facilitates pausing of RNA Pol II via H3K27me3-dependent chromatin condensation, leading to reduced gene expression of PCGs. Image was created with BioRender (https://www.biorender.com).

This Article

  1. Published in Advance March 11, 2024, doi: 10.1101/gr.278644.123 Genome Res. 34: 201-216

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