Table 4.
Gene sets enriched for positive selection in the most carnivorous mammals (carnivory score ≥90)
| Gene set | # Genes analyzed | Positively selected genes | P-value | Q-value |
|---|---|---|---|---|
| Reactome pathways | ||||
| O-linked glycosylation | 87 | ADAMTS5, ADAMTS12, ADAMTS14, ADAMTS20, B4GALT6, CHST4, LARGE2, THSD4 | 1.83 × 10−5 | 0.008 |
| Defective B3GLCT causes Peters-plus syndrome (PpS) | 34 | ADAMTS5, ADAMTS12, ADAMTS14, ADAMTS20, THSD4 | 7.70 × 10−5 | 0.013 |
| O-glycosylation of TSR domain-containing proteins | 35 | ADAMTS5, ADAMTS12, ADAMTS14, ADAMTS20, THSD4 | 8.89 × 10−5 | 0.013 |
| Diseases associated with O-glycosylation of proteins | 49 | ADAMTS5, ADAMTS12, ADAMTS14, ADAMTS20, THSD4 | 4.50 × 10−4 | 0.041 |
| Pregnenolone biosynthesis | 12 | CYP11A1, FDX2, STARD3NL | 4.58 × 10−4 | 0.041 |
| GO Terms | ||||
| GO:0008237 metallopeptidase activity | 158 | ADAMTS5, ADAMTS12, ADAMTS14, ADAMTS20, AEBP1, CNDP1, CPZ, PEPD, STAMBPL1, THSD4, TRHDE | 5.75 × 10−6 | 0.002 |
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We did not detect enrichment in the most herbivorous mammals (carnivory score ≤10).
