DNA-m6A calling and integrated long-read epigenetic and genetic analysis with fibertools

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Figure 4.
Figure 4.

fibertools nucleosome calling with PacBio and ONT Fiber-seq. (A) Data processing pipelines for nucleosome calling with fibertools. (B) Density of nucleosome lengths called by fibertools for PacBio (pink) and ONT (blue) Fiber-seq (n = 500,000 nucleosomes). (C) Visualization of the NAPA and HMBS representative loci for PacBio (top) and ONT (bottom) Fiber-seq. m6A calls from fibertools (PacBio) or Dorado (ONT) are represented by vertical purple dashes, along with nucleosome (gray) and MTase-sensitive patch (MSP; orange) calls from fibertools.

This Article

  1. Published in Advance June 7, 2024, doi: 10.1101/gr.279095.124 Genome Res. 34: 1976-1986

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