Cover image

This Special Issue on Long-read DNA Sequencing Applications in Biology and Medicine, Guest Edited by Drs. Ana Conesa, Alexander Hoischen, and Fritz Sedlazeck, is Part 1 of at least two issues focusing on original research offering novel biological and clinical insights gained using long-read DNA and RNA sequencing technologies and other long molecule approaches. Significant advances in long-read sequencing analysis methods and their implementation, as well as community resources, are also highlighted. On the cover, long strands representing DNA and RNA emerge from a cross section of a cell, with nucleosomes visible within. Primary colors represent different nucleotides. Floating circular motifs and the patterned background allude to characteristics of long-read sequencing technologies. The composition draws inspiration from Kandinsky, aiming to convey the inherent musicality of genetic material—the “music of life”—through the dynamic, whimsical forms of the lines and their vibrant color. (Illustration by Alex Cagan, University of Cambridge [https://www.alexcagan.com/].)