Figure 4.
CRE sequence conservation patterns across varying degrees of pleiotropy. (A,B) Number of weakly deleterious sites in humans (E.W.) inferred from human polymorphisms. It increases with increasing PD. (A) Separated by enhancers/promoters. (B) Separated by human–macaque accessibility conservation in NPCs. (C,D) Fraction of sites under (strong) negative selection on the lineage since the MRCA of humans and chimpanzees is the highest at the intermediately specific CREs and lowest in the pleiotropic CRE sequences. (C) Separated by enhancers/promoters. (D) Separated by human–macaque accessibility conservation in NPCs. (A–D) Depicted are mean values ± SEM.
