Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice

Table 1.

Results of tumor analysis

Mutyh KBrO3 concentrations
0% 0.05% 0.10% 0.15% 0.20%
+/+ Mean tumor number ± SD 0 0 0.4 ± 0.6 0.9 ± 1.0 0.9 ± 0.6
Tumor prevalence (%) 0 0 35.7 59.1 76.5
Number of mice analyzed 17 11 14 22 17
+/− Mean tumor number ± SD 0 0 1.4 ± 0.9 2.2 ± 1.2 3.2 ± 1.3
Tumor prevalence (%) 0 0 89.3 95.6 100
Number of mice analyzed 3 3 29 23 6
−/− Mean tumor number ± SD 0 0 8.8 ± 4.7 41.6 ± 12.7 61.9 ± 24.9
Tumor prevalence (%) 0 0 100 100 100
Number of mice analyzed 11 9 12 20 19

This Article

  1. Genome Res. 34: 47-56

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