Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice

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Figure 2.
Figure 2.

Dose-dependent increase in intestinal tumors in KBrO3-treated mice. Magenta, green, and blue dots and lines indicate the data of Mutyh−/−, Mutyh+/−, and Mutyh+/+, respectively. (A) The number of tumors per mouse is plotted based on genotype and KBrO3 dose. The line is drawn through the mean values. The pale-colored bands represent ± SD. (B) Tumor prevalence. The percentage of mice with tumor(s) in each study group is plotted against KBrO3 dose.

This Article

  1. Published in Advance January 30, 2024, doi: 10.1101/gr.278326.123 Genome Res. 34: 47-56

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