Gene-level analysis of 619 protein-coding genes. (A) Detected genes that have been linked to cognitive traits and brain-related disorders in previous GWASs. The novel and previously reported genes of human white matter are labeled with two different colors (red and blue, respectively). (B) Gene Ontology (GO) enrichment analysis for 619 protein-coding genes. At a FDR 5% level, the GO terms of 544 biological processes, 100 molecular functions, and 92 cellular components are significant. The top 10 of each category are shown. (C) GO enrichment analysis for 204 novel white matter–associated genes. At a FDR 5% level, the GO terms of 11 biological processes, three molecular functions, and 10 cellular components are significant.
