Impact of recombination gene haplo-insufficiency on APOBEC-induced mutagenesis in cervical cancers. (A) Median RSEM normalized RNA-seq expression values (middle horizontal bar in each box plot) for HPRT1, RAD51, and RAD51C in cervical cancers; one or two copies of each gene as determined by GISTIC analysis of SNP6 array data. Error bars indicate the range of RSEM expression values among tumors in each group. Tumors with two copies of RAD51 and RAD51C have higher expression of the respective genes than tumors with one copy as assessed by Mann–Whitney ranked sum test. (B) Minimal estimate of the number of APOBEC-induced mutations in cervical cancers with one or two copies of HPRT1, RAD51, and RAD51C. Median values are indicated by the middle bar in the box plots, and error bars indicate the range of values in each group. (C) Lack of correlation between the number of copy number variants (CNVs) and APOBEC-induced mutations in cervical cancers sequenced by TCGA. The Spearman's coefficient (rho) and P-value are indicated.
