ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development

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Figure 2.
Figure 2.

Tissue-level phenotypes of Zswim8−/− embryos. (A) Heart defect in Zswim8−/− embryos. Shown are representative images of H&E-stained transverse sections of hearts from Zswim8+/− and Zswim8−/− littermates at E18.5. Arrowhead points to a VSD. (B) Sacculation defect in Zswim8−/− embryos. Shown are lung sections from Zswim8+/+, Zswim8+/−, and Zswim8−/− embryos at the indicated developmental times immunostained for Podoplanin and Pro-surfactant C (green and magenta, respectively) and stained for DNA (Hoechst; blue). Scalebar represents 100 μm.

This Article

  1. Published in Advance August 2, 2023, doi: 10.1101/gr.278073.123 Genome Res. 33: 1482-1496

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