Deciphering D4Z4 CpG methylation gradients in fascioscapulohumeral muscular dystrophy using nanopore sequencing

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Figure 6.
Figure 6.

Methylation gradients in other CpG-dense repeat regions. (A) Manhattan plot of CpG density in 33 kb sliding windows (step size = 3.3 kb) across the T2T CHM13 v2.0 genome. Windows above 7% CpG density are marked as green dots. Alignment and methylation plots of untargeted reads from the C4 control (R10.4.1_e8.2 nanopores) mapped to (B) the LM-tRNA cluster on Chromosome 1 and (C) the 5S rRNA cluster on Chromosome 1. Mapped reads are anchored by unique flanking sequence and the two ends of the 5S rRNA cluster are shown separately.

This Article

  1. Published in Advance October 5, 2023, doi: 10.1101/gr.277871.123 Genome Res. 33: 1439-1454

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