Diffusion-enhanced characterization of 3D chromatin structure reveals its linkage to gene regulatory networks and the interactome

Validation of C_TG. (A) The Hi-C contact matrix (left), C_TG distance matrix (middle), and the median spatial distance matrix (right) of Chr 2 (resolution of 50 kb). (B) The Hi-C contact matrix (left), C_TG distance matrix (middle), and the median spatial distance matrix (right) of Chr 21 (resolution of 50 kb). (C) The correlation between the C_TG distance matrix and the median spatial distance matrix of Chr 2 and Chr 21. (D) The Spearman's correlation for the genomic sequence distance (top) and for the individual genomic region (bottom) between pairwise contact matrices derived from (1) normal colon tissue samples, (2) tumor colon tissue samples, (3) different numbers of 293 cells, and (4) repeated experiments on 293 cells. (***) P-value < 10⁻³⁰⁰ (t-test). (E) The MD plots between two normal colon tissue samples in view of genomic sequence distance.