Copy number variation alters local and global mutational tolerance

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Figure 4.
Figure 4.

Amplified genes result in increased mRNA expression. (A) Replicate averaged log2 fold-change of all genes on Chr XI in each CNV strain compared with the euploid ancestor. Numbers indicate the copy number of genes within the CNV. (B) Log2 of the fold-change in mRNA expression in the CNV compared with the ancestral euploid strain normalized by gene copy number for all genes amplified in each CNV strain.

This Article

  1. Published in Advance August 31, 2023, doi: 10.1101/gr.277625.122 Genome Res. 33: 1340-1353

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