Up-regulation of LTR retroelements in response to FZNF knockdown. (A) Cartoon showing design of MO-based FZNF knockdown experiment. (B) Log2 fold change versus P-value, comparing FiNZ translation blocking MO to scrambled MO control. (C) Log2 fold change comparison between old and young TE families, with “young” being defined as those whose median insertion age was less than 0.01 substitutions per site. P-values are Wilcoxon rank-sum tests comparing old and young in each TE class. (D) Log2 fold change of different FZNF categories. P-values are binomial tests for each category, assessing likelihood of seeing at least x up-regulated genes, assuming a null hypothesis in which there is a 50% chance of being either up- or down-regulated. Numbers below boxes in C and D give the number of data points per box.
