Integration site–dependent HIV-1 promoter activity shapes host chromatin conformation

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Figure 4.
Figure 4.

Impact of HIV-1 on genome-wide 3D chromatin conformation and H3K27ac enhancer loops at the integration site. Heatmap shows Knight–Ruiz (KR) normalized signal at 10-kb resolution surrounding their respective integration sites in Hi-C (A–C) and H3K27ac HiChIP (D–F). Heatmaps showing the Hi-C (G–I) and interaction (J–L) profiles at the same genomic window in lines with no HIV-1 integration into SPECC1 (G,H,J,K) and those with HIV-1 integrated into SPECC1 (I,L).

This Article

  1. Published in Advance June 9, 2023, doi: 10.1101/gr.277698.123 Genome Res. 33: 891-906

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