Cover image

Manhattan buildings represent Manhattan plots, which are a commonly used visualization technique for genome-wide association studies. The lights on the buildings represent single-nucleotide polymorphisms that have strong associations with the phenotype of interest. A mouse reveals a discovery hidden under the page—variants in a DNA repair gene, Msh3. In this issue, it is determined that inherited variants in Msh3 affect genome integrity by causing instability in lengths of short tandem repeats. (Cover design inspired by the children's Mouse Book series by Monique Felix. Cover illustration by Rahel Wachs, https://www.rubberduckillustration.com, Cynthia Wu, and Alon Goren. [For details, see Maksimov et al., pp. 689–702.])