Motif conservation, stability, and host gene expression are the main drivers of snoRNA expression across vertebrates

Host gene features vary considerably between snoRNA expression statuses. (A–D) Proportion of snoRNAs per expression status for C/D (left panel) and H/ACA box snoRNAs (right panel) according to their genomic context (A), their host gene function (B), promoter type (C), and sensitivity to nonsense-mediated decay (NMD) (D). (A) Fisher's exact test; (***) P < 5 × 10⁻⁶ and (***) P < 2 × 10⁻³², respectively, for C/D and H/ACA box snoRNAs. (C) Fisher's exact test; (***) P < 4 × 10⁻²⁸ and (***) P < 3 × 10⁻²⁵, respectively, for C/D and H/ACA box snoRNAs, and (**) P < 0.01. (D) Fisher's exact test; (***) P < 2 × 10⁻²⁷ and (***) P < 6 × 10⁻²², respectively, for C/D and H/ACA box snoRNAs, and (**) P < 0.01.