Comparison of TAD boundaries across different cell lines. (A) Hi-C contact maps and the corresponding TAD separation landscapes of a chromatin region in seven cell lines. (B) Clustering of multiple Hi-C samples from different cell lines based on their TAD separation landscapes. (C,D) The aggregated Hi-C contact maps around the GM12878-specific boundary regions (C) and K562-specific boundary regions (D) between comparison of the GM12878 and K562 cell lines, combined with the average boundary score profiles of the corresponding regions. The differences between these aggregated maps and the average boundary scores are also shown. (E) The contrastive Hi-C contact maps around a GM12878-specific boundary region (left) and a K562-specific boundary region (right). The Hi-C contact maps and corresponding boundary score profiles in GM12878 (marked in red) and K562 (marked in blue) are shown. The dashed lines and arrows indicate the location of the cell type–specific boundary regions.
