Comparison of TADs identified by 16 TAD-calling methods on Hi-C data from diverse cell lines. (A) TADs identified by different methods on the same chromatin region of GM12878 and K562. The results of six methods are shown, and the remaining ones are shown in Supplemental Figure S1B. (B) Comparison of measure of concordance (MoC) between TADs identified by different methods in GM12878 or K562 and between TADs identified by the same method in two cell lines, for the region in A. (C–F) Comparison of the difference in TAD number (C), TAD size (D), the Jaccard index between boundary sets (E), and the MoC between domain sets (F) across TADs identified by different methods on the same data set or across TADs identified by the same method on different data sets for seven human cell lines. The error bars represent the 95% confidence intervals. Mann–Whitney U tests are performed. (*) P-value < 0.0001.
