Characterization of network hierarchy reflects cell state specificity in genome organization

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Figure 3.
Figure 3.

Changes in hierarchy depth of CCN from human embryonic stem cells (hESCs) to three hESC-derived lineages. We defined the hierarchy depth of CCN as the negative of the median Poincaré radii (RP). (A) Bars showing the median Poincaré radii of Chr 11 for human embryonic stem cell (hESC), trophoblast-like cells (TBL), mesendoderm cells (MES), and neural progenitor cell (NPC). Corresponding Poincaré embedding structures are shown upon each bar. (B) Boxplot showing the median Poincaré radii of all intrachromosomal CCNs in each sample.

This Article

  1. Genome Res. 33: 247-260

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