Figure 2.
Poincaré embedding shows cell state–related hierarchy changes of CCNs in cancer and early embryo development. (A,B) Embedded structures of CCNs in the Poincaré disk for normal controls (left), cancer (middle), and cancer cell lines (right) of CRC and T-ALL. The color distribution of embedded nodes represents DNA sequential order. (C) Bars showing the median Poincaré radii (RP) of each sample with cell types varying from primary tissues, cancer, cancer cell lines, and early embryos. (D) Changes in the negative median Poincaré radii during human early embryo development and in cancer.
