Atlas-scale single-cell chromatin accessibility using nanowell-based combinatorial indexing

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Figure 1.
Figure 1.

Nanowell-based sciATAC-seq on mouse brain. (A) Experimental setup and workflow schematic using liquid handling robotics for high-index tagmentation and nanodispensing into 5184 well chips for PCR-based cell indexing. (B) UMAP projection of >420,000 mouse brain single-cell ATAC profiles. (C) Cell type module classification of clusters. (D) Marker gene accessibility plots for clusters.

This Article

  1. Published in Advance February 15, 2023, doi: 10.1101/gr.276655.122 Genome Res. 33: 208-217

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