Characterization of MER41-enhancers in different human tissues and trophoblast cells. (A) Enrichment of MER41 subfamilies in the epigenetically annotated enhancers for different human tissues. Enhancers were annotated as H3K27ac peaks that are more than 500 bp away from any TSSs. (B) The bar plot shows that, relative to distal genes, higher proportion of MER41-enhancer adjacent genes have increased expression in human placenta relative to mouse. MER41-enhancer adjacent genes are defined as those with their TSSs within 50 kb from any MER41-enhancers. P-value calculated using Fisher's exact test is indicated. (C) Enrichment of MER41 subfamilies in the enhancers annotated for human TSC, STB, and EVT. (D) Overlapping of the MER41-enhancers annotated for human TSC, STB, and EVT. (E) Heatmap shows the H3K27ac and H3K9me3 intensity for the shared or cell-specific MER41-enhancers for different human trophoblast cells. (F) IGV tracks showing the transcriptomic and epigenomic profiles surrounding the representative MER41-enhancer adjacent to FBN2.
