The frog sperm genome is organized without TADs and corner peaks. (A) Contact frequency as a function of genomic distance for Xenopus laevis (frog) sperm enriched by density gradient centrifugation (DGC) compared with frog XL-177 cells. (B) Normalized Hi-C matrices for the same samples as in A in the region of Chr1S:55–65 Mb at 25-kb resolution. (C) Number of TADs called for the same samples as in A. (D) Aggregate contact frequencies (coverage and distance corrected) around the 135 550- to 650-kb-long TADs called in XL-177 cells, for the same samples as in A. (E) Number of corner peaks called for the same samples as in A. (F) Aggregate contact frequencies (coverage and distance corrected) around the 109 550- to 650-kb-long corner peaks called in XL-177 cells, for the same samples as in A. (G) Normalized Hi-C matrices for the same samples as in A in the region of Chr3L:70–150 Mb at 100-kb resolution. (H) Compartment tracks from principal component analysis for the same samples as in A. (I) The autocorrelation of the PC1 value as a function of genomic distance, for the same samples as in A.
