Figure 2.
Published ATAC-seq profiles in sperm are dominated by cell-free chromatin contamination. (A) ATAC-seq browser tracks for sperm subject to the indicated conditions. (B) Heatmaps for the four indicated libraries, sorted into three categories: peaks specific to the untreated data set (I; n = 13,605), shared peaks (II; n = 2148), and peaks specific to DNase/DTT data sets (III; n = 8627). (C) Metagenes for <120-bp inserts, diagnostic of open chromatin, or for >150-bp inserts, diagnostic of nucleosome footprints, aligned over all annotated TSSs.
