Figure 3.
RPA and RAD51 binding in vivo in male mouse meiosis at asymmetric hotspots. (A) RPA binding to the DSB-initiating (above the x-axis) and repair template (below the y-axis) chromosomes in Dmc1−/− (left two plots; forward [F] and reverse [R] strands, respectively) and (B) Dmc1+/+ (right two plots; F and R strands, respectively) male mice (see also Fig. 1A). Dashed light blue and dark blue arrows highlight differences in binding between the wild type and mutant on the two homologs. (C,D) As in A,B but for RAD51.
