Genome-wide chromatin interaction profiling reveals a vital role of super-enhancers and rearrangements in host enhancer contacts during BmNPV infection

Enhancer-induced transcriptional stimulation on genes related to nucleosome assembly and BmNPV resistance is impeded after BmNPV infection. (A,B) Biological processes of KEGG terms (A) and GO terms (B) enriched in enhancer-associated genes. (C) Enrichment plots of the gene set related to nucleosome assembly. The GSEA result showed a significant and holistic down-regulation of the genes in this cluster. (D,E) Heatmap of the changes in enhancer-associated (D) and nonassociated (E) antiviral genes in mock- and BmNPV-infected cells at 48 h p.i. Data from three RNA-seq libraries are presented separately. Color-coding indicates log₂-transformed fold changes relative to mock infection. (F) Percentage of transcriptionally activated genes in the two categories of antiviral genes in D and E. Two-tailed t-test: (***) P < 10⁻⁶.