Figure 4.
A model for TRM evolution in Panagrolaimidae. If TBPs with affinity for TTAGGC telomeres could bind to any of the TTAGGC telomere, TTAGGC-containing unit clusters, or TTAGAC-containing unit clusters, they were able to construct a fully or partially stable telomere. This binding robustness of TBPs may have facilitated the TRM conversion from TTAGGC to TTAGAC. Even after TRM changed via mutation of the telomerase RNA component gene, if it occurred, TBPs could still bind to altered telomeric repeats, which possibly contributed to the evolution of a novel TRM, TTAGAC, in the Panagrolaimidae family.
