ESICCC as a systematic computational framework for evaluation, selection, and integration of cell-cell communication inference methods

Summary of properties and benchmarking results for the 18 LR inference methods. (A) The names of the 18 LR inference methods. (B) Properties of the 18 LR inference methods. We listed the strategy of each method for L/R scoring, LR scoring, intracellular signaling consideration, and multisubunit L/R complexes consideration. NA, not applicable; PEM, preferential expression score; RPS, regularized product score; PD, prior databases of LR interactions; PW, pathway-based LR scores. (C–F) The overall ranking (C, violet), accuracy (D, blue), stability (E, orange), and usability (F, yellow), as well as programming language for each method, were evaluated and visualized.