Figure 5.
A hypothesis for the mechanism underlying cell type–specific enhancers associated with commonly expressed genes. Schematic representation of the principle: Cell types A and B express different repertoires of TFs. TF X and Y are expressed in both cells but bind to different places, denoted as enhancer A and B in the two cell types, where there are optimal combinations of motifs in proximity that facilitate the collective binding of TFs expressed in each cell type.
