Figure 6.
Model for RISC-independent nuclear AGO2 function in germ cells during meiotic prophase. AGO2 interacts with chromatin and binds nearby nascent transcripts. At genes important for spermatogenic development, AGO2 maintains its interaction with the nuclear transcript and helps to stabilize and shuttle these transcripts to the cytoplasm, eventually resulting in increased protein expression and promoting sperm production. Diagrams created with BioRender (https://biorender.com).
